首站-论文投稿智能助手
典型文献
Alpha-Klotho in Parkinson's disease:a perspective on experimental evidence and potential clinical implications
文献摘要:
α-Klotho protein(KL)has been discovered more than 20 years ago,and immediately emerged as a master regulator of aging-related processes,which basically operates as an anti-aging factor.It is expressed through the entire human body,representing the choroid plexus and the kidney as the most active sources at the central nervous system(CNS)and periphery level respectively.To a lesser extent,also the parathyroid gland,the adipose tissue,and the liver express KL.
文献关键词:
作者姓名:
Piergiorgio Grillo;Michele Basilicata;Tommaso Schirinzi
作者机构:
Unit of Neurology,Department of Systems Medicine,University of Roma Tor Vergata,Rome,Italy;Department of Experimental Medicine and Surgery,University of Roma Tor Vergata,Rome,Italy
引用格式:
[1]Piergiorgio Grillo;Michele Basilicata;Tommaso Schirinzi-.Alpha-Klotho in Parkinson's disease:a perspective on experimental evidence and potential clinical implications)[J].中国神经再生研究(英文版),2022(12):2687-2688
A类:
B类:
Alpha,Klotho,Parkinson,disease,perspective,experimental,evidence,potential,clinical,implications,protein,KL,has,been,discovered,more,than,years,ago,immediately,emerged,master,regulator,aging,related,processes,which,basically,operates,anti,It,expressed,through,entire,human,body,representing,choroid,plexus,kidney,most,active,sources,central,nervous,system,CNS,periphery,level,respectively,To,lesser,extent,also,parathyroid,gland,adipose,tissue,liver
AB值:
0.775221
相似文献
FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells
Yuan-Yang Tan;Hui-Qin Zhou;Yu-Jing Lin;Liu-Tong Yi;Zhuang-Gui Chen;Qing-Dong Cao;Yan-Rong Guo;Zhao-Ni Wang;Shou-Deng Chen;Yang Li;De-Yun Wang;Yong-Kang Qiao;Yan Yan-Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center,the Fifth Affiliated Hospital,Sun Yat-Sen University,Zhuhai 519000,Guangdong,China;Department of Pathology,the Fifth Affiliated Hospital,Sun Yat-Sen University,Zhuhai 519000,Guangdong,China;Department of Pediatrics,the Third Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510630,China;Department of Cardiothoracic Surgery,the Fifth Affiliated Hospital,Sun Yat-Sen University,Zhuhai 519000,Guangdong,China;Department of Otolaryngology,Yong Loo Lin School of Medicine,National University Health System,National University of Singapore,Singapore 119228,Singapore;BGI-Shenzhen,Shenzhen 518083,Guangdong,China;Central Laboratory,the Fifth Affiliated Hospital,Sun Yat-Sen University,Zhuhai 519000,Guangdong,China
TRDMT1 exhibited protective effects against LPS - induced inflammation in rats through TLR4- NF- κB / MAPK- TNF - α pathway
Zhengguang Li;Xiaolong Qi;Xu Zhang;Lei Yu;Lijuan Gao;Weining Kong;Wei Chen;Wei Dong;Lijun Luo;Dan Lu;Lianfeng Zhang;Yuanwu Ma-Key Laboratory of Human Disease Comparative Medicine,National Health Commission of China(NHC),Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences,Peking Union Medicine College,Beijing,China;National Human Diseases Animal Model Resource Center and Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases,Institute of Laboratory Animal Science,Peking Union Medicine College,Chinese Academy of Medical Sciences,Beijing,China;Neuroscience Center,Chinese Academy of Medical Sciences,Beijing,China
Targeted lipidomics reveals plasmalogen phosphatidylethanolamines and storage triacylglycerols as the major systemic lipid aberrations in Bietti crystalline corneoretinal dystrophy
Shijing Wu;Sin Man Lam;Huajin Li;Binhua Jiang;Zixi Sun;Tian Zhu;Xing Wei;Xuan Zou;Guanghou Shui;Ruifang Sui-Department of Ophthalmology,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;Department of Ophthalmology,The First Affiliated Hospital of Fujian Medical University,Fuzhou,Fujian 350004,China;LipidALL Technologies Company Limited,Changzhou,Jiangsu 213022,China
Alzheimer's disease:current status and perspective
Wenying Liu;Serge Gauthier;Jianping Jia-Innovation Center for Neurological Disorders and Department of Neurology,Xuanwu Hospital,Capital Medical University,National Clinical Research Center for Geriatric Diseases,Beijing 100053,China;Departments of Neurology and Neurosurgery,and Department of Psychiatry,McGill Centre for Studies in Aging,McGill University,Montreal H4H1R3,Canada;Beijing Key Laboratory of Geriatric Cognitive Disorders,Beijing 100053,China;Clinical Center for Neurodegenerative Disease and Memory Impairment,Capital Medical University,Beijing 100053,China;Center of Alzheimer's Disease,Beijing Institute of Brain Disorders,Collaborative Innovation Center for Brain Disorders,Capital Medical University,Beijing 100053,China;Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing 100053,China
Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function
Xiang Xu;Guangjin Ding;Caizhi Liu;Yuhan Ding;Xiaoxin Chen;Xiaoli Huang;Chen-Song Zhang;Shanxin Lu;Yunpeng Zhang;Yuanyong Huang;Zhaosu Chen;Wei Wei;Lujian Liao;Shu-Hai Lin;Jingya Li;Wei Liu;Jiwen Li;Sheng-Cai Lin;Xinran Ma;Jiemin Wong-Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,East China Normal University,Shanghai,China;Zhongshan-Xuhui Hospital,Fudan University and Shanghai Key Laboratory of Medical Epigenetics,the International Co-laboratory of Medical Epigenetics and Metabolism,Ministry of Science and Technology,Institutes of Biomedical Sciences,Fudan University,Shanghai,China;Department of Biochemistry and Department of Cardiology of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang,China;State Key Laboratory of Cellular Stress Biology,Innovation Center for Cell Signaling Network,School of Life Sciences,Xiamen University,4221 South Xiang'an Road,Xiamen,Fujian,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,China;Department of Biochemistry and Molecular Biology,Program in Molecular and Cell Biology,Zhejiang University School of Medicine,Hangzhou,Zhejiang,China;Joint Center for Translational Medicine,Fengxian District Central Hospital,6600 Nanfeng Road,Shanghai,China
Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139
Yali Zhou;Henrik Daver;Boris Trapkov;Lijie Wu;Meng Wu;Kasper Harps?e;Patrick R.Gentry;Kaiwen Liu;Marina Larionova;Junlin Liu;Na Chen;Hans Br(a)uner-Osborne;David E.Gloriam;Tian Hua;Zhi-Jie Liu-iHuman Institute,ShanghaiTech University,Shanghai,China;School of Life Science and Technology,ShanghaiTech University,Shanghai,China;University of Chinese Academy of Sciences,Beijing,China;CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Shanghai,China;Department of Drug Design and Pharmacology,University of Copenhagen,Universitetsparken 2,Copenhagen,Denmark;Photobiology laboratory,Institute of Biophysics SB RAS,Federal Research Center "Krasnoyarsk Science Center SB RAS",Akademgorodok 50/50,Krasnoyarsk,Russia
Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growth in vitro and patient-derived xenografts in vivo
Fanxiang Yin;Ran Zhao;Dhilli Rao Gorja;Xiaorong Fu;Ning Lu;Hai Huang;Beibei Xu;Hanyong Chen;Jung-Hyun Shim;Kangdong Liu;Zhi Li;Kyle Vaughn Laster;Zigang Dong;Mee-Hyun Lee-Department of Pathophysiology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China;China-US(Henan)Hormel Cancer Institute,Zhengzhou 450008,China;Translational Medical Center,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;The Hormel Institute,University of Minnesota,Austin,MN 55912,USA;Department of Biomedicine,Health&Life Convergencen Science,BK21 Four,College of Pharmacy,Mokpo National University,Jeonnam 58554,Republic of Korea;The Collaborative Innovation Center of Henan Province for Cancer Chemoprevention,Zhengzhou 450001,China;Department of General Surgery,the Affiliated Tumor Hospital of Zhengzhou University,Zhengzhou 450008,China;College of Korean Medicine,Dongshin University,Naju 58245,Republic of Korea
Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway
Yi-kuan Wu;Zheng-nan Ren;Sheng-long Zhu;Yun-zhou Wu;Gang Wang;Hao Zhang;Wei Chen;Zhao He;Xian-long Ye;Qi-xiao Zhai-State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China;School of Medicine,Jiangnan University,Wuxi 214122,China;College of Life Science,Northeast Agricultural University,Harbin 150038,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi 214122,China;Shandong Key Laboratory of Endocrinology and Lipid Metabolism,Jinan 250021,China;School of Medicine,Shandong University,Jinan 250012,China;Ganjiang Chinese Medicine Innovation Center,Nanchang 330000,China
机标中图分类号,由域田数据科技根据网络公开资料自动分析生成,仅供学习研究参考。