典型文献
DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer 's disease
文献摘要：
The amyloid-β (Aβ) oligomer, rather than the Aβ monomer, is considered to be the primary initiator of Alzheimer's disease. It was hypothesized that p(Aβ3–10)10-MT, the recombinant Aβ3–10 gene vaccine of the Aβ oligomer has the potential to treat Alzheimer's disease. In this study, we intramuscularly injected the p(Aβ3–10)10-MT vaccine into the left hindlimb of APP/PS1/tau triple-transgenic mice, which are a model for Alzheimer's disease. Our results showed that the p(Aβ3–10)10-MT vaccine effectively reduced Aβ oligomer levels and plaque deposition in the cerebral cortex and hippocampus, decreased the levels tau protein variants, reduced synaptic loss, protected synaptic function, reduced neuron loss, and ameliorated memory impairment without causing any cerebral hemorrhaging. Therefore, this novel DNA vaccine, which is safe and highly effective in mouse models of Alzheimer's disease, holds a lot of promise for the treatment of Alzheimer's disease in humans.
文献关键词：
中图分类号：
作者姓名：
Sha Sha;Xiao-Na Xing;Tao Wang;Ying Li;Rong-Wei Zhang;Xue-Li Shen;Yun-Peng Cao;Le Qu
作者机构：
Department of Geriatrics,the First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China;Department of Neurology,Shenzhen Luohu People's Hospital,The Third Affiliated Hospital of Shenzhen University,Shenzhen,Guangdong Province,China;College of Life and Health Sciences,Northeastern University,Shenyang,Liaoning Province,China;Department of Neurology,the First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China;Department of Dermatology,the First Affiliated Hospital of China Medical University,Shenyang,Liaoning Province,China
文献出处：
引用格式：
[1]Sha Sha;Xiao-Na Xing;Tao Wang;Ying Li;Rong-Wei Zhang;Xue-Li Shen;Yun-Peng Cao;Le Qu-.DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer 's disease)[J].中国神经再生研究（英文版）,2022(10):2305-2310
A类：
intramuscularly,hemorrhaging
B类：
vaccines,targeting,amyloid,oligomer,cognitive,deficits,aged,PS1,tau,triple,transgenic,mouse,models,Alzheimer,disease,rather,than,monomer,considered,be,primary,initiator,It,was,hypothesized,that,MT,recombinant,gene,has,potential,In,this,study,injected,into,left,hindlimb,mice,which,are,Our,results,showed,effectively,reduced,levels,plaque,deposition,cerebral,cortex,hippocampus,decreased,protein,variants,synaptic,loss,protected,function,neuron,ameliorated,memory,impairment,without,causing,any,Therefore,novel,safe,highly,holds,lot,promise,treatment,humans
AB值：
0.55192
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