典型文献
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease
文献摘要：
Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy loss, axonal degeneration, and mitochondrial dysfunction. Axonal degeneration is an early hallmark of neurodegeneration and is triggered by SARM1. We found that depletion or dysfunctional mutation of SARM1 protected against NAD+ loss, axonal degeneration, and mitochondrial functional disorder induced by the neurotoxic peptide PrP106–126. NAD+ supplementation rescued prion-triggered axonal degeneration and mitochondrial dysfunction and SARM1 overexpression suppressed this protective effect. NAD+ supplementation in PrP106–126-incubated N2a cells, SARM1 depletion, and SARM1 dysfunctional mutation each blocked neuronal apoptosis and increased cell survival. Our results indicate that the axonal degeneration and mitochondrial dysfunction triggered by PrP106–126 are partially dependent on SARM1 NADase activity. This pathway has potential as a therapeutic target in the early stages of prion disease.
文献关键词：
中图分类号：
作者姓名：
Meng-Yu Lai;Jie Li;Xi-Xi Zhang;Wei Wu;Zhi-Ping Li;Zhi-Xin Sun;Meng-Yang Zhao;Dong-Ming Yang;Dong-Dong Wang;Wen Li;De-Ming Zhao;Xiang-Mei Zhou;Li-Feng Yang
作者机构：
National Animal Transmissible Spongiform Encephalopathy Laboratory,College of Veterinary Medicine,China Agricultural University,Beijing,China
文献出处：
引用格式：
[1]Meng-Yu Lai;Jie Li;Xi-Xi Zhang;Wei Wu;Zhi-Ping Li;Zhi-Xin Sun;Meng-Yang Zhao;Dong-Ming Yang;Dong-Dong Wang;Wen Li;De-Ming Zhao;Xiang-Mei Zhou;Li-Feng Yang-.SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease)[J].中国神经再生研究（英文版）,2022(10):2293-2299
A类：
SARM1,neurogenerative,Axonal,PrP106,NADase
B类：
participates,axonal,mitochondrial,prion,Prion,represents,group,fatal,diseases,humans,animals,that,are,associated,energy,loss,early,hallmark,neurodegeneration,triggered,by,We,found,depletion,dysfunctional,mutation,protected,against,NAD+,disorder,induced,neurotoxic,peptide,supplementation,rescued,overexpression,suppressed,this,protective,effect,incubated,N2a,cells,each,blocked,neuronal,apoptosis,increased,survival,Our,results,indicate,partially,dependent,activity,This,pathway,has,potential,therapeutic,target,stages
AB值：
0.436838
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
