典型文献
DNAzyme as a rising gene-silencing agent in theranostic settings
文献摘要：
Decades of biochemical studies have advanced DNA beyond its primary role as genetic blueprint.DNAzymes are single-stranded enzymatic DNA molecules that do not exist in nature.They are ideal candidates for gene silencing owing to their scalability by solid-phase synthesis (without batch variations),reprogrammability by directed evolution and local sequence alterations,compatibility with diverse delivery methods,and capability of achieving high catalytic turnover independent of any auxiliary proteins.With these unique features,various artificially evolved DNAzymes have been employed as theranostic tools in designing biosensors and logic gates,RNA/DNA cleavage and ligation,phosphorylation and dephosphorylation,DNA photorepair,and peptide side-chain modifications,to name but a few (Ponce-Salvatierra et al.,2021).This perspective will focus on the functional aspects and therapeutic potentials of RNA-cleaving DNAzymes.
文献关键词：
中图分类号：
作者姓名：
Nan Zhang
作者机构：
Neuroscience Program,Department of Neurology,Houston Methodist Research Institute,Houston,TX,USA
文献出处：
引用格式：
[1]Nan Zhang-.DNAzyme as a rising gene-silencing agent in theranostic settings)[J].中国神经再生研究（英文版）,2022(09):1989-1990
A类：
DNAzymes,reprogrammability,photorepair,Ponce,Salvatierra
B类：
rising,silencing,agent,theranostic,settings,Decades,biochemical,studies,have,advanced,beyond,its,primary,role,genetic,blueprint,are,single,stranded,enzymatic,molecules,that,do,not,exist,nature,They,ideal,candidates,owing,their,scalability,by,solid,phase,synthesis,without,batch,variations,directed,evolution,local,sequence,alterations,compatibility,diverse,delivery,methods,capability,achieving,high,catalytic,turnover,independent,any,auxiliary,proteins,With,these,unique,features,various,artificially,evolved,been,employed,tools,designing,biosensors,logic,gates,cleavage,ligation,dephosphorylation,peptide,side,chain,modifications,name,but,few,This,perspective,will,focus,functional,aspects,therapeutic,potentials,cleaving
AB值：
0.703945
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