典型文献
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease
文献摘要：
Autophagy has been shown to play an important role in Parkinson's disease.We hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson's disease through affecting autophagy.In this study,6-hydroxydopamine-damaged SH-SY5Y cells were pretreated with a culture medium containing skin-derived precursors differentiated into Schwann cells(SKP-SCs).The results showed that the SKP-SC culture medium remarkably enhanced the activity of SH-SY5Y cells damaged by 6-hydroxydopamine,reduced excessive autophagy,increased tyrosine hydroxylase expression,reduced α-synuclein expression,reduced the autophagosome number,and activated the PI3K/AKT/mTOR pathway.Autophagy activator rapamycin inhibited the effects of SKP-SCs,and autophagy inhibitor 3-methyladenine had the opposite effect.These findings confirm that SKP-SCs modulate the PI3K/AKT/mTOR pathway to inhibit autophagy,thereby exhibiting a neuroprotective effect in a cellular model of Parkinson's disease.This study was approved by the Animal Ethics Committee of Laboratory Animal Center of Nantong University(approval No.S20181009-205)on October 9,2018.
文献关键词：
中图分类号：
作者姓名：
Jia-Nan Yan;Hai-Ying Zhang;Jun-Rui Li;Ying Chen;Yong-Cheng Jiang;Jia-Bing Shen;Kai-Fu Ke;Xiao-Su Gu
作者机构：
Department of Neurology,Affiliated Hospital of Nantong University,Nantong,Jiangsu Province,China;Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong,Jiangsu Province,China;Department of Clinical Medicine,The First Clinical Medical College of Xuzhou Medical University,Xuzhou,Jiangsu Province,China;Department of Neurology and Suzhou Clinical Research Center of Neurological Disease,The Second Afflicted Hospital of Soochow University,Suzhou,Jiangsu Province,China
文献出处：
引用格式：
[1]Jia-Nan Yan;Hai-Ying Zhang;Jun-Rui Li;Ying Chen;Yong-Cheng Jiang;Jia-Bing Shen;Kai-Fu Ke;Xiao-Su Gu-.Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson's disease)[J].中国神经再生研究（英文版）,2022(06):1357-1363
A类：
Nantong,S20181009
B类：
Schwann,cells,differentiated,from,skin,derived,precursors,provide,neuroprotection,via,autophagy,inhibition,cellular,model,Parkinson,disease,Autophagy,has,been,shown,play,important,role,We,hypothesized,that,neuroprotective,effects,through,affecting,In,this,study,hydroxydopamine,damaged,SH,SY5Y,were,pretreated,culture,medium,containing,into,SKP,SCs,results,showed,remarkably,enhanced,activity,reduced,excessive,increased,tyrosine,hydroxylase,expression,synuclein,autophagosome,number,activated,PI3K,AKT,mTOR,pathway,activator,rapamycin,inhibited,inhibitor,methyladenine,had,opposite,These,findings,confirm,modulate,thereby,exhibiting,This,was,approved,Animal,Ethics,Committee,Laboratory,Center,University,approval,No,October
AB值：
0.558611
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