典型文献
All roads lead to Rome—a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer's disease
文献摘要：
Age-related neurodegenerative disorders such as Alzheimer's disease(AD)have become a critical public health issue due to the significantly extended human lifespan,leading to considerable economic and social burdens.Traditional therapies for AD such as medicine and surgery remain ineffective,impractical,and expensive.Many studies have shown that a variety of bioactive substances released by physical exercise(called"exerkines")help to maintain and improve the normal functions of the brain in terms of cognition,emotion,and psychomotor coordination.Increasing evidence suggests that exerkines may exert beneficial effects in AD as well.This review summarizes the neuroprotective effects of exerkines in AD,focusing on the underlying molecular mechanism and the dynamic expression of exerkines after physical exercise.The findings described in this review will help direct research into novel targets for the treatment of AD and develop customized exercise therapy for individuals of different ages,genders,and health conditions.
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作者姓名：
Yi-Yao Liang;Li-Dan Zhang;Xi Luo;Li-Li Wu;Zhao-Wei Chen;Guang-Hao Wei;Kai-Qing Zhang;Ze-An Du;Ren-Zhi Li;Kwok-Fai So;Ang Li
作者机构：
Guangdong-Hong Kong-Macau Institute of CNS Regeneration,Jinan University,Guangzhou,Guangdong Province,China;Key Laboratory of CNS Regeneration(Jinan University),Ministry of Education,Guangzhou,Guangdong Province,China;Department of Medical Ultrasonics,Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,Guangdong Province,China;Guangdong Key Laboratory of Liver Disease Research,Sun Yat-sen University,Guangzhou,Guangdong Province,China;Department of Clinical Medicine,School of Medicine,Jinan University,Guangzhou,Guangdong Province,China;Department of Clinical Medicine,International School,Jinan University,Guangzhou,Guangdong Province,China;International Department of the Affiliated High School of South China Normal University,Guangzhou,Guangdong Province,China;Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China
文献出处：
引用格式：
[1]Yi-Yao Liang;Li-Dan Zhang;Xi Luo;Li-Li Wu;Zhao-Wei Chen;Guang-Hao Wei;Kai-Qing Zhang;Ze-An Du;Ren-Zhi Li;Kwok-Fai So;Ang Li-.All roads lead to Rome—a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer's disease)[J].中国神经再生研究（英文版）,2022(06):1210-1227
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0.689555
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
