典型文献
Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke
文献摘要：
Cerebral ischemia and resultant energy collapse: The ischemic stroke is a complex neurological condition that can be devastating for patients and their families. This disease is the second leading cause of death worldwide and is characterized by a sudden decrease in cerebral blood flow due to major blood vessel blockage. Ischemic stroke generates two damaged zones with distinctive metabolic characteristics. The first is the ischemic core, the region directly irrigated by the occluded artery. A reduction to less than 20％ of the baseline blood flow levels defines the area; therefore, depletion of glucose and adenosine triphosphate (ATP) cause an irreversible failure in the energy metabolism that leads to loss of ionic homeostasis, acidosis, and necrosis. The second is the region surrounding the ischemic core, called the penumbra, characterized by significantly depressed tissue perfusion that is barely sufficient to support basal oxygen, glucose, and ATP levels. The penumbra represents a region at risk that is functionally impaired but potentially recoverable and suitable for neuroregeneration. Therefore, physiological conditions must be reestablished rapidly after ischemia to avoid a permanent metabolic failure in the penumbra.
文献关键词：
中图分类号：
作者姓名：
Iván Alquisiras-Burgos
作者机构：
Laboratorio de Patología Vascular Cerebral,Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez,Insurgentes Sur#3877,Col.La Fama,Tlalpan,Ciudad de México,México
文献出处：
引用格式：
[1]Iván Alquisiras-Burgos-.Involvement of glucose transporter overexpression in the protection or damage after ischemic stroke)[J].中国神经再生研究（英文版）,2022(04):783-784
A类：
neuroregeneration,reestablished
B类：
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AB值：
0.634807
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
