典型文献
A simple human cell model for TAU trafficking and tauopathy-related TAU pathology
文献摘要：
The microtubule (MT)-associated protein TAU is highly abundant in the axon of human brain neurons, where it binds to and stabilizes MT filaments. Thereby, TAU regulates the dynamic (dis)assembly of MT strands and is involved in a wide range of neuronal functions. In Alzheimer's disease (AD) and other tauopathies, TAU is missorted into the somatodendritic compartment. TAU missorting is accompanied by (or leads to) abnormal TAU phosphorylation, MT destabilization, and loss of dendritic spines and mitochondria, eventually resulting in TAU aggregation, neuronal dysfunction and cell death (Arendt et al., 2016). Strikingly, the mechanisms of TAU sorting, and the detrimental cascade upon its failure, are still not fully understood.
文献关键词：
中图分类号：
作者姓名：
Michael Bell
作者机构：
Institute of Human Genetics,Faculty of Medicine and University Hospital Cologne,University of Cologne;Center for Molecular Medicine Cologne(CMMC),University of Cologne,Cologne,Germany
文献出处：
引用格式：
[1]Michael Bell-.A simple human cell model for TAU trafficking and tauopathy-related TAU pathology)[J].中国神经再生研究（英文版）,2022(04):770-772
A类：
tauopathy,tauopathies,missorted,somatodendritic,missorting,Arendt
B类：
simple,human,cell,model,TAU,trafficking,related,pathology,microtubule,MT,associated,protein,highly,abundant,axon,brain,neurons,where,binds,stabilizes,filaments,Thereby,regulates,dynamic,assembly,strands,involved,wide,range,neuronal,functions,In,Alzheimer,disease,AD,other,into,compartment,accompanied,leads,abnormal,phosphorylation,destabilization,loss,spines,mitochondria,eventually,resulting,aggregation,dysfunction,death,Strikingly,mechanisms,detrimental,cascade,upon,its,failure,are,still,not,fully,understood
AB值：
0.552658
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