典型文献
Female sex in experimental traumatic brain injury research: forging a path forward
文献摘要：
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with estimates indicating that ～50％ of the world's population will acquire a head injury at some point in their lifetime (Maas et al., 2017). Mild TBIs account for ～80％ of all reported cases, with up to 43％ of all TBI patients reporting symptoms beyond 2 weeks post-injury. As of 2016, only 7％ of preclinical TBI experiments included both male and female sexes, and fewer studies analyzed the data using sex as a biological variable (Spani et al., 2018). Since 2016, there has been a bigger push for TBI research to include both sexes, due to reports of sex disparities in symptom presentation, recovery, and vulnerability to other neurological disorders; emphasizing how little we know about the pathophysiology of TBI in females. In this Perspective, we discuss some preclinical and clinical sex differences, challenges addressing female inclusion in preclinical TBI research, and potential solutions towards finding a balance between female sex inclusion and sex as an independent biological variable; forging a path towards improving scientific rigor, reproducibility and inclusivity for evaluating pathophysiological sex-differences after TBI.
文献关键词：
中图分类号：
作者姓名：
Theresa Currier Thomas
作者机构：
Department of Child Health,University of Arizona College of Medicine-Phoenix;BARROW Neurological Institute at Phoenix Children's Hospital,Phoenix,AZ,USA;Phoenix VA Health Care System,Phoenix,AZ,USA;Arizona State University,Tempe,AZ,USA
文献出处：
引用格式：
[1]Theresa Currier Thomas-.Female sex in experimental traumatic brain injury research: forging a path forward)[J].中国神经再生研究（英文版）,2022(03):550-552
A类：
TBIs,Spani
B类：
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AB值：
0.57828
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