典型文献
Emerging small-molecule therapeutic approaches for Alzheimer 's disease and Parkinson's disease based on targeting microRNAs
文献摘要：
The role of microRNAs in the progression of neurodegenerative diseases: MicroRNAs (miRNAs) are endogenous, non-coding and short RNA nucleotides that regulate gene expression through base pairing with the targeted messenger RNA (mRNA) at the 3′untranslated region (3′ UTR). Thus, miRNAs play fundamental role in the inhibition or degradation of messenger RNAs (Gebert and MacRae, 2019). Two ribonuclease (RNase)Ⅲ enzymes control the biogenesis of miRNAs; Drosha and Dicer. The first step in the biogenesis includes the cleavage of primary miRNAs (pri-miRNAs) in cell nucleus by Drosha, which leads to the formation of short stem-loop pre-miRNAs. Subsequently, these pre-miRNAs are transported to the cytoplasm and further processed by Dicer resulting in mature miRNAs (O'Brien et al., 2018).
文献关键词：
中图分类号：
作者姓名：
Somaya A.Abdelrahman
作者机构：
Department of Medicinal Chemistry,Faculty of Pharmacy,Mansoura University,Mansoura,Egypt;Department of Radiology,Stanford University School of Medicine,Stanford,CA,USA
文献出处：
引用格式：
[1]Somaya A.Abdelrahman-.Emerging small-molecule therapeutic approaches for Alzheimer 's disease and Parkinson's disease based on targeting microRNAs)[J].中国神经再生研究（英文版）,2022(02):336-337
A类：
Gebert,MacRae,Drosha
B类：
Emerging,small,molecule,therapeutic,approaches,Alzheimer,Parkinson,targeting,microRNAs,role,progression,neurodegenerative,diseases,MicroRNAs,miRNAs,are,endogenous,coding,short,nucleotides,that,regulate,expression,through,pairing,targeted,messenger,untranslated,region,UTR,Thus,play,fundamental,inhibition,degradation,Two,ribonuclease,RNase,enzymes,control,biogenesis,Dicer,first,step,includes,cleavage,primary,cell,nucleus,by,which,leads,formation,stem,loop,Subsequently,these,transported,cytoplasm,further,processed,resulting,mature,Brien
AB值：
0.572102
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