典型文献
Cholesterol synthesis inhibition or depletion in axon regeneration
文献摘要：
Cholesterol is biosynthesized by all animal cells. Beyond its metabolic role in steroidogenesis, it is enriched in the plasma membrane where it has key structural and regulatory functions. Cholesterol is thus presumably important for post-injury axon regrowth, and this notion is supported by studies showing that impairment of local cholesterol reutilization impeded regeneration. However, several studies have also shown that statins, inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase, are enhancers of axon regeneration, presumably acting through an attenuation of the mevalonate isoprenoid pathway and consequent reduction in protein prenylation. Several recent reports have now shown that cholesterol depletion, as well as inhibition of cholesterol synthesis per se, enhances axon regeneration. Here, I discussed these findings and propose some possible underlying mechanisms. The latter would include possible disruptions to axon growth inhibitor signaling by lipid raft-localized receptors, as well as other yet unclear neuronal survival signaling process enhanced by cholesterol lowering or depletion.
文献关键词：
中图分类号：
作者姓名：
Bor Luen Tang
作者机构：
Department of Biochemistry,Yong Loo Lin School of Medicine,National University Health System,National University of Singapore,Singapore
文献出处：
引用格式：
[1]Bor Luen Tang-.Cholesterol synthesis inhibition or depletion in axon regeneration)[J].中国神经再生研究（英文版）,2022(02):271-276
A类：
prenylation
B类：
Cholesterol,synthesis,inhibition,depletion,axon,regeneration,biosynthesized,by,all,animal,cells,Beyond,its,metabolic,role,steroidogenesis,enriched,plasma,membrane,where,has,key,structural,regulatory,functions,thus,presumably,important,post,injury,regrowth,this,notion,supported,studies,showing,that,impairment,cholesterol,reutilization,impeded,However,several,have,also,shown,statins,inhibitors,hydroxy,methylglutaryl,CoA,reductase,are,enhancers,acting,through,attenuation,mevalonate,isoprenoid,pathway,consequent,reduction,protein,Several,recent,reports,now,well,per,enhances,Here,discussed,these,findings,propose,some,possible,underlying,mechanisms,latter,would,include,disruptions,signaling,lipid,raft,localized,receptors,other,yet,unclear,neuronal,survival,process,enhanced,lowering
AB值：
0.656322
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
