典型文献
Unmodified methodologies in target discovery for small molecule drugs:A rising star
文献摘要：
Target discovery,involving target identification and validation,is the prerequisite for drug discovery and screening.Novel methodologies and technologies for the precise discovery and confirmation of drug tar-gets are powerful tools in understanding the disease,looking for a drug and elucidating the mechanism of drug treatment.Among the common target identification and confirmation methods,the modified method is time-consuming and laborious,which may reduce or change the activity of natural products.The unmodified methods developed in recent years without chemical modification have gradually be-come an important means of studying drug targets.A wide range of unmodified approaches have been reported,introducing and analyzing the recent emerging methodologies and technologies.This review highlights the advantages and limitations of these methods for the application of drug target discovery and presents an overview of their contributions to the target discovery of small molecule drugs.The application and future development trends of methodologies in target discovery are also prospected to provide a reference for drug target research.
文献关键词：
中图分类号：
作者姓名：
Jiayue Tang;Meng Ou;Qiuling Zheng;Ya Ding
作者机构：
Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China Pharmaceutical University,Nanjing 210009,China;State Key Laboratory of Natural Medicines,Department of Pharmaceutical Analysis,College of Pharmacy,China Pharmaceutical University,Nanjing 210009,China
文献出处：
引用格式：
[1]Jiayue Tang;Meng Ou;Qiuling Zheng;Ya Ding-.Unmodified methodologies in target discovery for small molecule drugs:A rising star)[J].中国化学快报（英文版）,2022(12):4980-4988
A类：
Unmodified
B类：
methodologies,discovery,small,molecule,drugs,rising,star,Target,involving,identification,validation,prerequisite,screening,Novel,technologies,precise,confirmation,are,powerful,tools,understanding,disease,looking,elucidating,mechanism,treatment,Among,common,methods,consuming,laborious,which,may,reduce,change,activity,natural,products,unmodified,developed,recent,years,without,chemical,modification,have,gradually,come,important,means,studying,targets,wide,range,approaches,been,reported,introducing,analyzing,emerging,This,review,highlights,advantages,limitations,these,application,presents,overview,their,contributions,future,development,trends,also,prospected,provide,reference,research
AB值：
0.536758
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