典型文献
Radiotherapy assisted with biomaterials to trigger antitumor immunity
文献摘要：
As an extensively applied therapeutic approach to combat tumors,radiotherapy generates localized ioniz-ing radiation to destruct tumor cells.Despite its importance in clinical oncology,radiotherapy would often cause significant organ toxicity,and its therapeutic effect is limited by tumor hypoxia.Moreover,although abscopal therapeutic effects have occasionally been observed,radiotherapy is still mostly employed as a local treatment method that could hardly control tumor metastases.In recent years,strategies involving biomaterials and nanomedicine have received increasingly high attention to enhance cancer radiotherapy.Beyond sensitizing tumors for radiotherapy via various mechanisms,many biomaterial systems with im-mune stimulating effects have also been introduced to boost the antitumor immunity post cancer radio-therapy.In this mini-review,we will summarize the progress of different biomaterials and nanomedicine systems in combination with radiotherapy to trigger antitumor immune responses and enhance the ef-ficacy of immunotherapy,and discusses the perspectives and challenges of this research direction aimed at clinical translations.
文献关键词：
中图分类号：
作者姓名：
Xiaojun Yu;Haitao Ma;Guiying Xu;Zhuang Liu
作者机构：
Department of Thoracic Surgery,Dushu Lake Hospital Affiliated to Soochow University,Suzhou 215021,China;Department of Cardiothoracic Surgery,Children,s Hospital of Soochow University,Suzhou 215021,China;Institute of Functional Nano&Soft Materials(FUNSOM),Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices,Soochow University,Suzhou 215123,China
文献出处：
引用格式：
[1]Xiaojun Yu;Haitao Ma;Guiying Xu;Zhuang Liu-.Radiotherapy assisted with biomaterials to trigger antitumor immunity)[J].中国化学快报（英文版）,2022(09):4169-4174
A类：
ioniz
B类：
Radiotherapy,assisted,biomaterials,trigger,antitumor,immunity,extensively,applied,therapeutic,approach,combat,tumors,radiotherapy,generates,localized,radiation,destruct,cells,Despite,its,importance,clinical,oncology,would,often,cause,significant,organ,toxicity,limited,by,hypoxia,Moreover,although,abscopal,effects,have,occasionally,been,observed,still,mostly,employed,treatment,method,that,could,hardly,control,metastases,In,recent,years,strategies,involving,nanomedicine,received,increasingly,high,attention,enhance,cancer,Beyond,sensitizing,via,various,mechanisms,many,systems,stimulating,also,introduced,boost,post,this,mini,review,we,will,summarize,progress,different,combination,immune,responses,ficacy,immunotherapy,discusses,perspectives,challenges,research,direction,aimed,translations
AB值：
0.62238
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