典型文献
Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy
文献摘要：
Metal-organic frameworks (MOFs) have recently allured a variety of concern in the fields of nanotech-nology.However,exploring their biomedical applications is still a relatively new field.In this work,ze-olite imidazole skeleton-8 (ZIF-8) was reported for the first time as a drug carrier for the treatment of lung injury.Uniform ZIF-8 nanoparticles encapsulating plumbagin (PLB) are achieved by a facile physi-cal adsorption process.Scanning electron microscopy (SEM),powder X-ray diffraction (PXRD) and UV-vis absorption spectrum were conducted to investigate the physical properties of ZIF-8 and PLB@ZIF-8.In an-imal model,the collagen fibers deposition produced by severe lung injury is significantly decreased.The secretion of inflammatory factor TGF-β and IL-6 were efficiently dropped by the combination of plumba-gin and ZIF-8.At the same time,the expressions of collagen I,α-SMA and TNF-α were also suppressed.This strategy puts forth a promising blueprint in the application of MOF materials,especially in biomed-ical fields.
文献关键词：
中图分类号：
作者姓名：
Yang Wang;Qing Li;Mengsheng Deng;Kuijun Chen;Jianmin wang
作者机构：
State Key Laboratory of Trauma,Burns and Combined Injury,Department of Surgical Research,Daping Hospital,Army Medical University,Chongqing 400042,China;School of Chemistry and Chemical Engineering,Yangzhou University,Yangzhou 225002,China
文献出处：
引用格式：
[1]Yang Wang;Qing Li;Mengsheng Deng;Kuijun Chen;Jianmin wang-.Self-assembled metal-organic frameworks nanocrystals synthesis and application for plumbagin drug delivery in acute lung injury therapy)[J].中国化学快报（英文版）,2022(01):324-327
A类：
plumbagin,allured,olite,plumba
B类：
Self,assembled,metal,organic,frameworks,nanocrystals,synthesis,drug,delivery,acute,lung,injury,therapy,Metal,MOFs,have,recently,variety,concern,fields,nanotech,nology,However,exploring,their,biomedical,applications,still,relatively,new,In,this,ze,imidazole,skeleton,ZIF,was,reported,first,carrier,treatment,Uniform,nanoparticles,encapsulating,PLB,are,achieved,by,facile,adsorption,process,Scanning,electron,microscopy,powder,ray,diffraction,PXRD,UV,vis,absorption,spectrum,were,conducted,investigate,physical,properties,imal,model,collagen,fibers,deposition,produced,severe,significantly,decreased,secretion,inflammatory,TGF,efficiently,dropped,combination,At,same,expressions,SMA,also,suppressed,This,strategy,puts,forth,promising,blueprint,materials,especially
AB值：
0.620422
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