典型文献
Diamide derivatives containing a trifluoromethylpyridine skeleton: Design, synthesis, and insecticidal activity
文献摘要：
Diamide derivatives are biologically active molecules that have been widely applied in recent years in research on pesticides, especially insecticides. Using a simple and environmentally friendly scheme, a series of new diamide derivatives containing a trifluoromethylpyridine skeleton was designed, synthesized, and confirmed by 1H, 19F and 13C NMR, and HR-MS. Their insecticidal activities against Plutella xylostella and Helicoverpa armigera were measured and the relationship between structure and activity was investigated. Eight of the title compounds (D2, D5, D10, D21, D28, D29, D30 and D33) showed 100％ activity against P. xylostella at 500 mg L–1. One compound, D33, still showed 100％ activity against P. xylostella at 100 mg L–1 and had the lowest LC50 (lethal concentration 50％, 3.7 mg L–1) among the synthesized compounds. Molecular docking analysis revealed that D33 could be thoroughly embedded in the active pocket of the ryanodine receptor via hydrogen bonding in a manner similar to the commercial insecticide chlorantraniliprole.
文献关键词：
中图分类号：
作者姓名：
XU Fang-zhou;WANG Yan-yan;GUO Sheng-xin;DAI A-li;WU Jian
作者机构：
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering/Key Laboratory of Green Pesticide and Agricultural Bioengineering,Ministry of Education/Guizhou University,Guiyang 550025,P.R.China
文献出处：
引用格式：
[1]XU Fang-zhou;WANG Yan-yan;GUO Sheng-xin;DAI A-li;WU Jian-.Diamide derivatives containing a trifluoromethylpyridine skeleton: Design, synthesis, and insecticidal activity)[J].农业科学学报（英文）,2022(10):2995-3003
A类：
Diamide,trifluoromethylpyridine,diamide,chlorantraniliprole
B类：
derivatives,containing,skeleton,Design,synthesis,insecticidal,activity,are,biologically,active,molecules,that,have,been,widely,applied,recent,years,research,pesticides,especially,insecticides,Using,simple,environmentally,friendly,scheme,series,new,was,designed,synthesized,confirmed,by,1H,19F,13C,NMR,Their,activities,against,Plutella,xylostella,Helicoverpa,armigera,were,measured,relationship,between,structure,investigated,Eight,title,compounds,D5,D10,D21,D28,D29,D30,D33,showed,One,still,had,lowest,LC50,lethal,concentration,among,Molecular,docking,analysis,revealed,could,thoroughly,embedded,pocket,ryanodine,receptor,via,hydrogen,bonding,manner,similar,commercial
AB值：
0.63134
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
