典型文献
Immunology and immunotherapy in breast cancer
文献摘要：
Immuno-oncology is a rapidly developing field in medicine. Drug combination therapies have already been studied in many clinical trials on various tumor types. In recent years, a checkpoint inhibition therapy with monoclonal antibodies targeting PD-1 and its ligand PD-L1 has been developed. Breast cancer had been examined in the field of immune-oncology relatively recently. This review focuses on clinical evidence regarding immune checkpoint inhibition for curative treatment of various breast cancer subtypes. In addition, we present the results of studies demonstrating the prognostic and predictive value of levels of tumor-infiltrating lymphocytes (CD4 and CD8), their quantitative ratios, and their correlation with regulatory genes (PD-1, PD-L1, and FOX-P3).
文献关键词：
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作者姓名：
Vladimir Semiglazov;Andrey Tseluiko;Asel Kudaybergenova;Anna Artemyeva;Petr Krivorotko;Roman Donskih
作者机构：
Petrov National Medicine Cancer-Research Center Ministry of Health,Saint-Petersburg 197758,Russia
文献出处：
引用格式：
[1]Vladimir Semiglazov;Andrey Tseluiko;Asel Kudaybergenova;Anna Artemyeva;Petr Krivorotko;Roman Donskih-.Immunology and immunotherapy in breast cancer)[J].癌症生物学与医学（英文版）,2022(05):609-618
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B类：
Immunology,immunotherapy,breast,cancer,oncology,rapidly,developing,field,medicine,Drug,combination,therapies,have,already,been,studied,many,clinical,trials,various,tumor,In,years,checkpoint,inhibition,monoclonal,antibodies,targeting,its,ligand,L1,has,developed,Breast,had,examined,immune,relatively,recently,This,review,focuses,evidence,regarding,curative,treatment,subtypes,addition,we,present,results,studies,demonstrating,prognostic,predictive,value,levels,infiltrating,lymphocytes,CD4,CD8,their,quantitative,ratios,correlation,regulatory,genes,FOX,P3
AB值：
0.686012
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