典型文献
Research progress in hepatitis B virus covalently closed circular DNA
文献摘要：
Hepatitis B virus (HBV) infections are a global public health issue. HBV covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs, is a key factor in the HBV replication cycle. Notably, many host factors involved in HBV cccDNA epigenetic modulation promote the development of hepatocellular carcinoma (HCC). The HBV cccDNA minichromosome is a clinical obstacle that cannot be efficiently eliminated. In this review, we provide an update on the advances in research on HBV cccDNA and further discuss factors affecting the modulation of HBV cccDNA. Hepatitis B virus X protein (HBx) contributes to HBV cccDNA transcription and the development of hepatocarcinogenesis through modulating host epigenetic regulatory factors, thus linking the cccDNA to hepatocarcinogenesis. The measurable serological biomarkers of continued transcription of cccDNA, the effects of anti-HBV drugs on cccDNA, and potential therapeutic strategies targeting cccDNA are discussed in detail. Thus, this review describes new insights into HBV cccDNA mechanisms and therapeutic strategies for cleaning cccDNA, which will benefit patients with liver diseases.
文献关键词：
中图分类号：
作者姓名：
Xiaodong Zhang;Yufei Wang;Guang Yang
作者机构：
Department of Gastrointestinal Cancer Biology,Liver Cancer Center,Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin,Tianjin's Clinical Research Center for Cancer,Tianjin 300060,China;Department of Cancer Research,College of Life Sciences,Nankai University,Tianjin 300071,China
文献出处：
引用格式：
[1]Xiaodong Zhang;Yufei Wang;Guang Yang-.Research progress in hepatitis B virus covalently closed circular DNA)[J].癌症生物学与医学（英文版）,2022(04):415-431
A类：
hepatocarcinogenesis
B类：
Research,progress,hepatitis,virus,covalently,closed,circular,Hepatitis,HBV,infections,are,global,public,health,issue,cccDNA,template,transcription,viral,RNAs,key,replication,cycle,Notably,many,host,factors,involved,epigenetic,modulation,promote,development,hepatocellular,carcinoma,HCC,minichromosome,clinical,obstacle,that,cannot,efficiently,eliminated,In,this,review,we,provide,update,advances,research,further,affecting,protein,HBx,contributes,through,modulating,regulatory,thus,linking,measurable,serological,biomarkers,continued,effects,anti,drugs,potential,therapeutic,strategies,targeting,discussed,detail,Thus,describes,new,insights,into,mechanisms,cleaning,which,will,benefit,patients,liver,diseases
AB值：
0.558905
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