Background: The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers during the past 30 years.Methods: We extracted data of kidney, bladder, and prostate cancers from the Global Burden of Disease 2019 database, including incidence, mortality, disability-adjusted life-years (DALYs), and attributable risk factors from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to assess the changes in age-standardized incidence rate, age-standardized mortality rate (ASMR), and age-standardized DALYs rate (ASDR). The associations between cancers burden and socio-demographic index (SDI) were also analyzed. Results: Compared with 1990, the global incident cases in 2019 were higher by 154.78％, 123.34％, and 169.11％ for kidney, bladder, and prostate cancers, respectively. During the 30-year study period, there was a downward trend in ASMR and ASDR for bladder cancer (EAPC=–0.68 and –0.83, respectively) and prostate cancer (EAPC=–0.75 and –0.71, respectively), but an upward trend for kidney cancer (EAPC=0.35 and 0.12, respectively). Regions and countries with higher SDI had higher incidence, mortality, and DALYs for all three types of cancers. The burden of bladder and prostate cancers was mainly distributed among older men, whereas the burden of kidney cancer increased among middle-aged men. Smoking related mortality and DALYs decreased, but high body mass index (BMI) and high fasting plasma glucose (FPG) related mortality and DALYs increased among kidney, bladder, and prostate cancers during the study period. Conclusions: Kidney, bladder, and prostate cancers remain major global public health challenges, but with distinct trend for different disease entity across different regions and socioeconomic status. More proactive intervention strategies, at both the administrative and academic levels, based on the dynamic changes, are needed.

Hao Zi;Shao‑Hua He;Xie‑Yuan Leng;Xiao‑Feng Xu;Qiao Huang;Hong Weng;Cong Zhu;Lu‑Yao Li;Jia‑Min Gu;Xu‑Hui Li;Dao‑Jing Ming;Xiao‑Dong Li;Shuai Yuan;Xing‑Huan Wang;Da‑Lin He;Xian‑Tao Zeng

Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Center for Evidence?Based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Precision Medicine Centre,the Second People's Hospital of Huaihua,Huaihua 418000,Hunan,China;the First School of Clinical Medicine,Anhui Medical University,Hefei 230000,China;Department of Urology,Xianyang Central Hospital,Xianyang 712000,Hubei,China;Department of Urology,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Institutes of Evidence?Based Medicine and Knowledge Translation,Henan University,Kaifeng 475000,Henan,China;Department of Urology,Huaihe Hospital of Henan University,Kaifeng 475000,Henan,China;Institute of Urology,Wuhan University,Wuhan 430071,China

军事医学研究（英文）

[1]Hao Zi;Shao‑Hua He;Xie‑Yuan Leng;Xiao‑Feng Xu;Qiao Huang;Hong Weng;Cong Zhu;Lu‑Yao Li;Jia‑Min Gu;Xu‑Hui Li;Dao‑Jing Ming;Xiao‑Dong Li;Shuai Yuan;Xing‑Huan Wang;Da‑Lin He;Xian‑Tao Zeng-.Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019)[J].军事医学研究（英文）,2022(03):303-318

ASDR

Global,regional,national,burden,kidney,bladder,prostate,cancers,their,attributable,risk,factors,Background,has,changed,recent,decades,This,study,aims,investigate,global,genitourinary,during,past,years,Methods,We,extracted,from,Burden,Disease,database,including,incidence,mortality,disability,adjusted,life,DALYs,Estimated,annual,percentage,changes,EAPC,were,calculated,assess,standardized,ASMR,associations,between,demographic,SDI,also,analyzed,Results,Compared,incident,cases,higher,by,respectively,During,period,there,was,downward,trend,upward,Regions,countries,had,three,types,mainly,distributed,among,older,men,whereas,increased,middle,aged,Smoking,related,decreased,body,mass,fasting,plasma,glucose,FPG,Conclusions,Kidney,remain,major,public,health,challenges,distinct,different,disease,entity,across,regions,socioeconomic,status,More,proactive,intervention,strategies,both,administrative,academic,levels,dynamic,needed

0.456305